Tough to say. I have the #5 in mine and am contemplating taking manning unless alexander slips to me. Someone like Westbrook might be available and worth taking especially if receptions count in your league.
Don't be surprised if Joseph Addai is the 2nd best fantasy RB this season. Addai and Kitna are two guys that will, if drafted at the right moments, will bring in alot of fantasy points at a relatively cheap value.
I play in a 12 team league and I am usually last to take a qb. Also make my last picks kickers and defenses.FWIW, I would NEVER considering picking a QB that early unless you are in a 2 QB starter league or some bizarre scoring league (like passing TDs are the same as rushing TDs). That said, I am the guy that has only once drafted a QB before the 5th round and that was in unique circumstances.